On March 7, 2018, José Ramón Barreto and Irene Esser were confirmed as protagonists of the first part of the story. Luis Gerónimo Abreu and Shany Nadan was also confirmed as Manuela Sáenz.
Filming of the series began in March 2018 in Cartagena, Colombia. The series is shot in Colombia and cities such as Villa de Leyva, Monguí, Calí, Popayán, Los Nevados National Natural Park, El Páramo de Oceta and the Eastern Plains of Colombia. In May 2018 the production moved to Toledo, Spain, and with the help of Galdo Media they shot some scenes on the Lavaderos de Rojas estate. The series is also shot between the border of Venezuela and Colombia.
Maximiliano Gómez as Child Simón
Luis Gerónimo Abreu as Simón Bolívar
José Ramón Barreto as Young Simón
Irene Esser María Teresa Rodríguez del Toro y Alayza (Bolívar's Wife )
Shany Nadan as Manuela Sáenz
Rosmeri Marval as María Antonia Bolívar
Ricardo Mejía as Juan Vicente Bolívar
Nohely Arteaga María de la Concepción Palacios y Blanco (Bolívar's Mother )
Abril Schreiber
Mauro Donetti as Feliciano Palacios de Aguirre y Ariztía-Sojo y Gil de Arratia (Bolivar's Grandfather)
Patricia Tamayo
Andrés Poveda
Margoth Velásquez as Tomasa (Matea Bolívar's mother )
Carlos Gutiérrez as Joaquin Montesinos
Álvaro Bayona as Carlos Palacios (Bolívar's Uncle)
Ernesto Benjumea as Simón Rodríguez (Bolívar's teacher )
Hans Martínez Francisco de Paula Santander
Erick Rodríguez as Pablo Clemente Palacios (María Antonia Bolivar's husband)
Bárbara Perea as Hipolita Bolívar
Ana Harlem as Matea Bolívar
Jefferson Quiñonez
Quique Mendoza as Esteban Palacios (Bolívar's uncle)
Bernardo García as Pedro Palacios
Nicolás Prieto as Andrés Bello
Manuel José Chaves as Julio Herrera
José María Galeano as Felipe Martínez y Aragón
Before the series premiered, it was heavily criticised by Venezuelan President Nicolás Maduro, who was angry about potential defamation, wanting to preserve Bolívar's image and tell everyone that Bolívar was Venezuelan, not Colombian, saying the other country was " running a hate campaign".