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The house mouse (Mus musculus) is a small mammal of the order Rodentia, characteristically having a pointed snout, small rounded ears, and a long naked or almost hairless tail. It is one of the most abundant species of the genus Mus. Although a wild animal, the house mouse mainly lives in association with humans.

The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was sequenced in 2002. Laboratory mice derived from the house mouse are by far the most common mammalian species used in genetically engineered models for scientific research.

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