The Battle of Issus occurred in southern Anatolia, on November 5, 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Empire, led by Darius III, in the second greatbattle of Alexander 's conquest of Asia. The invading Macedonian troops defeated Persia. After the Hellenic League soundly defeated the Persian satraps of Asia Minor (led by Greek mercenary Memnon of Rhodes ) at the Battle of the Granicus, Darius took personal command of his army. He gathered reinforcements and led his men in a surprise march behind the Hellenic advance to cut their line of supply. This forced Alexander to countermarch, setting the stage for the battle near the mouth of the Pinarus River and the town of Issus.
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